Change is a notable feature of our time. Indeed, we expect that the world we live in will soon be significantly different, as will our lives and the lives of the communities we belong to. Because of technology, because of environmental degradation and, last but not least, because of the influence of rising powers on the world economy and the rules-based international order, the adaptation required at all levels is of unprecedented magnitude. The vastness of the task can be translated into effective decision-making by organizations of various sorts, from states to companies, only if all of them engage change, make sense of phenomena that spawn innovation, and anticipate the often-multidimensional impact of those phenomena. In-depth understanding of relevant global issues and knowledge-based foresight are key to steering change according to one’s worldview, mission and broader, long-term aims.